IGHE and atopic eczema: PLE was reported to have an inhibitory effect on T cell activation via reduction of interleukin (IL)‐2 production in vitro; an additional in vivo animal model of atopic dermatitis resulted in reduced IgE levels, mast cell infiltration, and pro‐inflammatory cytokine expressions, especially Th2 cytokines, after oral administration of PLE, suggesting its role in inflammatory skin diseases such as atopic dermatitis.1