CDKN2A and hepatocellular carcinoma: This promotes the accumulation of senescent cells, which shows a strong correlation with increased hepatic fibrosis in hepatocellular carcinoma (HCC) and the overexpression of p16 and p21 (Paradis et al., 2001; El-Serag and Rudolph, 2007; Desai et al., 2019) (Figure 2).