GCKR and Hypoglycemia: In hypoglycemia, GKRP binds to GCK to inactivate it and thus prevent GCK from entering the nucleus, reducing glucose decomposition and raising blood sugar; When blood sugar rises, GKRP separates from GCK, and the GCK in the nucleus restarts and returns to the cytoplasm, promoting glycolysis and lowering plasma glucose levels.