CD81 and overnutrition: Previous work has shown that adipocytes uptake endothelial cell-derived sEVs in vitro and in vivo and this process is impaired by overnutrition.6 In vitro studies have shown that CD81 protein delivered to cultured cells via sEVs is functional,7,8 which suggests that intercellular transfer of CD81+ sEVs in vivo allows recipient cells to “adopt” functions attributable to CD81.