CD81 and obesity due to melanocortin 4 receptor deficiency: Recent discoveries by Oguri et al. have demonstrated that CD81 preserves cardiometabolic health via integrin-dependent signaling in white adipose tissue.3 In their study, the authors demonstrated that CD81 is both necessary and sufficient for de novo beige adipogenesis,3 an adaptation that increases energy expenditure and may be a treatment for obesity and other metabolic diseases.