TP53 and renal fibrosis: Our recently published data (Li and Gong, 2023) on Rhizoma Chuanxiong and Radix et Rhizoma Rhei (rhubarb) against AKI and renal fibrosis based on network pharmacology and experimental validation shows that this herbal drug pair might inhibit tubular epithelial cell apoptosis and improve AKI and renal fibrosis by inhibiting p38 MAPK/p53 signaling.