As illustrated in (Figures 8A, B), the A2AR is linked to the invasive breast cancer signature, oncogenic and angiogenic signaling pathways (Myc, VEGF and IL6-JAK-STAT3) as well as proliferation, metastasis, hypoxia, adhesion and cell cycle processes (Rac1 GTPASE cycle). The gene discussed is ADORA2A; the disease is breast cancer.