Subsequently, investigating the profile of tumor-infiltrating cell, we found that compared to the A2ARlow phenotype, TME with a strong A2AR expression had an increased proportion of protumoral cells, including M0 and M2 macrophages, different subsets of Tregs (Tr1, nTreg and iTreg), exhausted T CD8+ cells and CD4+ memory resting T cells. Here, CD4 is linked to neoplasm.