EA pretreatment at ST36 and BL13 acupoints for 5 days significantly increased the plasma CO content, reduced MDA and MPO, the number of apoptotic cells in the lung, and wet/dry (W/D) lung weight ratio, and reduced ALI caused by endotoxic shock, whereas acupuncture at non-acupoints showed no significant effect. The gene discussed is MPO; the disease is acute respiratory distress syndrome.