TNF and serum lipopolysaccharide activity: In addition, pretreatment of acupoint Hegu (LI4) with EA can significantly reduce the release of serum proinflammatory factors, such as TNF-α, IL-1β, and IL-6; therefore, it can reduce the systemic inflammatory reaction, significantly improve the survival rate of rats with fatal endotoxemia, and EA at LI 4 has a stronger protective effect than at PC6 acupoint, while electrical stimulation of non-acupoints is ineffective.