Among these, the Nrf-2/HO-1, PI3K/Akt/Nrf2/HO-1, JAK1/STAT3, SIRT1/NF-κB, HO-1/PINK1, calpain-2/STAT3, and PICK1-TLR4 signalling pathways may be involved in the effects of acupuncture on the inhibition of the inflammatory response, reduction of oxidative stress, and protection of mitochondrial damage in the target organs of sepsis (Figure 2). Here, TLR4 is linked to Sepsis.