However, when a large number of pathogens invade, immune cells are overactivated, resulting in the release of numerous inflammatory factors, such as tumor necrosis factor-α (TNF-α), interleukin-1beta (IL-1beta), IL-6, and IL-17, which form a storm of inflammatory factors and initiate a sepsis-like network reaction. The gene discussed is IL1B; the disease is Sepsis.