Acupuncture may increase PICK1-TLR4 complex formation, reduce plasma NSE levels and inhibit inflammatory reactions through the acetylcholine pathway, protect mitochondrial function by activating the Nrf-2/HO-1 pathway, increase p-eNOS, and reduce Aβ deposition, thus alleviating hippocampus damage during sepsis. This evidence concerns the gene NFE2L2 and Sepsis.