Exosomal circPDK1 acts as a scaffold to enhance the interaction between ubiquitin conjugating enzyme E20 (UBE2O) and bridging integrator 1 (BIN1), and it induces UBE2O-mediated degradation of BIN1, a protein that inhibits tumor progression by suppressing c-myc transcriptional activity. This evidence concerns the gene BIN1 and neoplasm.