CRC-delivered exosomal nuclear receptor interacting protein 1 circRNA (circNRIP1) activates the AKT/mTOR pathway to promote the Warburg effect (74), whereas circ-0005963 promotes glycolysis and induces oxaliplatin resistance via the miRNA 122/pyruvate kinase muscle isozyme M2 (miR-122/PKM2) pathway (75). The gene discussed is AKT1; the disease is colorectal carcinoma.