IL-22BP was also present at higher concentrations in sera from patients with SSc-ILD [36.3 ng/mL (18.7-57.8)], with a progressive decrease in SSc without ILD [24.7 ng/mL (13.7-50.8)] and HC [20.4 ng/mL (13.9-37.6); p = 0.02 SSc-ILD vs. HC]. Here, IL22RA2 is linked to systemic sclerosis.