In comparison to patients with skin involvement (i.e., dcSSc and lcSSc), patients with SSc sine scleroderma exhibited lower serum levels of leptin [0.18 ng/mL (0-1.21) in sine vs. 2.58 ng/mL (0.79-4.70) in the other subsets; p = 0.03], and higher levels of aldolase A [123 ng/mL (116-148) in sine vs. 84.7 ng/mL (74.7-96) in the other subsets; p = 0.003]. The gene discussed is LEP; the disease is systemic sclerosis.