We observed significantly higher levels of serum Ang2 in SSc, especially in SSc-ILD compared to HC [median (IQR): 1.15 ng/mL (0.60-2.41) in SSc, 1.45 ng/mL (0.79-3.09) in SSc-ILD, 0.58 ng/mL (0.34-0.82) in HC; p = 0.0001 for both comparisons]. This evidence concerns the gene ANGPT2 and systemic sclerosis.