While we initially observed higher MMP-12 levels in SSc patients during SOMAscan analysis, we found significantly lower values during ELISA validation, especially in SSc-ILD, early SSc, and anti-Scl-70 or anti-RNA polymerase III positivity, suggesting a potential correlation between serum MMP-12 levels and milder forms of the disease. This evidence concerns the gene MMP12 and systemic sclerosis.