SSc-ILD patients showed elevated serum levels of proteins involved in intracellular signaling and cell cycle regulation (FCRL3, PDE11, Stratifin), as well as increased levels of MCP-3, a monocyte chemoattractant, and sICAM-5, the ligand for leukocyte adhesion protein LFA-1, compared to patients without ILD. This evidence concerns the gene FCRL3 and systemic sclerosis.