GPT and Decreased liver function: Also, liver dysfunction characterized by jaundice, hepatomegaly, and elevation in liver enzymes (alanine transaminase [ALT], aspartate aminotransferase [AST], ALP [alkaline phosphatase]) can be seen in patients with TA-GVHD. On the other hand, respiratory and central nervous system involvements leading to shortness of breath, hypoxemia, aseptic meningitis, encephalitis, and seizures may occur in some patients with TA-GVHD [17,29,30].