The highest quartile of Klotho had significant 34% lower odds of skin cancer (OR, 0.66; 95% CI, 0.45-0.96; P =.03) than the lowest quartile; the odds for melanoma were not significant (OR, 0.69; 95%CI, 0.36-1.33; P =.26). This evidence concerns the gene KL and skin neoplasm.