In the current study, ITGB1 and ITGA5 acted as receptors for the extracellular matrix, and elevated expression of IGTB1 enhances the invasive and proliferative capacity of hepatocellular carcinoma by accelerating the cell cycle process through the PXN/YWHAZ/AKT pathway, whereas ITGA5 was considered to be a prognostic and independent risk factor [49,50]. This evidence concerns the gene ITGA5 and hepatocellular carcinoma.