PDE4D and posterior cortical atrophy: A study by Wedge et al. (2018) investigating genomic rearrangements via whole genome sequencing of >100 PCa tissue samples identified losses at chr5:60–100 Mb in ETS-negative tumors, as well as homozygous deletions within chr5:55–59 Mb (region encoding PDE4D) in ETS-positive tumors [9].