Located on chromosomes 16, 22 and 17 respectively, the FUS (Fused In Sarcoma or TLS, for Translocated in Liposarcoma), EWSR1 (Ewing sarcoma breakpoint region 1 also known as EWS) and TAF15 (TATA-binding protein-associated factor 15, also known as TAF2N) genes belong to the FET family of RNA-binding proteins. The gene discussed is EWSR1; the disease is sarcoma.