Specifically, we detected the expression of growth‐associated proteins, and found EE promoted the expression of the GAP‐43 and synaptogenesis marker SYN in the bilateral hippocampus and right cortex in line with previous studies, which indicated that EE might stimulate hippocampal and cortical structural plasticity involving axonal sprouting and synaptogenesis in animals after ischemia.46 Here, GAP43 is linked to ischemia.