rLEL-Ov-TSP-3 induced upregulated expression in cholangiocytes of Il-8, a potent chemoattractant, implying that this process may drive cell migration through the chemokine receptors, CXCR1 and CXCR2, both of which are highly expressed in cancer cells and can trigger liver cell migration and invasion (Bi et al. 2019). This evidence concerns the gene THBS3 and cancer.