In addition, ROS stress led to mRNA down‐regulation of KIF11, and ROS scavenger Tempol rescued this change to a certain extent (Figure S3D). To further assess mRNA down‐regulation of KIF11 in senescent hepatoma cells, we cloned the KIF11 promoter region (2 kb upstream of the 5' end of gene) into a transcriptionally active luciferase reporter plasmid. The cells were then transiently transferred into HepG2 cells to construct short‐acting KIF11 transcriptional activity reporter cells. The gene discussed is KIF11; the disease is hepatocellular carcinoma.