We then used liver‐specific Kif11 knockout (Kif11fl/wt;Alb‐Cre+/−) mice and WT (Kif11fl/wt) littermates to determine their tumorigenesis in a mouse model of HCC. We found that the malignant degree (Figure 7K) and weight (Figure 7L) of liver tumours in Kif11fl/wt;Alb‐Cre+/− group were lower than those in the WT mice.  Furthermore, SA‐β‐Gal activity, p16 and p19 (p14 in human) were up‐regulated in liver cancer tissues of the Kif11fl/wt;Alb‐Cre+/− mice compared with the Kif11fl/wt mice (Figures 7M and N). This evidence concerns the gene KIF11 and liver cancer.