KL and neoplasm: Histone lactylation has been identified as an epigenic modification type for regulating gene transcription.[13a] Recent studies have revealed that histone lactylation occurs widely in human and mouse cells, and controls microglial function, cardiac repair, tumor progression, and inflammation.[13, 16, 34] During osteoblast differentiation, histone lactylation of the mouse osteoblast precursor cell line increased, suggesting that histone lactylation may participate in osteogenesis.[14] Our data showed decreased pan‐Kla and H3K18la lactylation in BMSCs isolated from PSkm2ΔEC and OVX mice.