GPX1 and cancer: PCBP1 is an RBP that is ubiquitously expressed in human cells and is considered as a potential tumor suppressor for many types of cancers, including gastric cancer.[31, 35, 36, 37] Mechanism study discovered that circMAP2K2 can disrupt the protein stability of PCBP1 through proteasomes degradation, and the alteration of PCBP1 further affect the expression of GPX1.