CapanR cells were characterized by enhanced mRNA expression of microsomal triglyceride transfer protein (MTTP), the fatty acid importer CD36, and PNPLA2 together with a decrease of FASN, GPAT2, and DGAT2 (Figure S1c, Supporting Information), indicating a switch toward enhanced lipid uptake, intracellular trafficking and utilization upon BOLD‐100 resistance development in the pancreatic cancer model. Here, DGAT2 is linked to familial pancreatic carcinoma.