NF2 and neoplasm: We subsequently performed GSEA using the hallmark collection in MSigDB v.2023.1 and found that the differentially expressed genes in NF2 patients’ compared to sporadic NF2-altered tumours were significantly overrepresented in signatures associated with 'Allograft rejection' (FDR q-value < 0.001), 'Interferon gamma response' (FDR q-value = 0.015), 'Inflammatory response' (FDR q-value = 0.043), and 'Complement' (FDR q-value = 0.038) (Fig. 2E, Additional file 2: Table S4).