TP53 and central nervous system cancer: Our group has developed a minipig model of high-grade SCG using lentiviral gene transfer of oncogenic transgenes including platelet derived growth factor beta (PDGF-B), HRAS-G12V, and small hairpin-loop RNA targeting P53 (shRNA-P53) [10] as well a vetted methodology for inducing glioma in prior rodent studies[11–13] and validated this approach in the rat spinal cord [14].