GLP1R and type 2 diabetes mellitus: We previously demonstrated, in the trial called Effect of Liraglutide on Vascular Inflammation in Type-2 Diabetes (LiraFlame26), that treatment with the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (1.8 mg/d) downregulated several lipid species, including ceramides in individuals with T2D, using an untargeted lipidomic approach [27].