CD8A and neoplasm: For tumor microenvironment, the infiltration of CD3+CD8+ cells in LDC@ZnP-MA NPs + NIR treated group was 4.9-, 3.9-, 2.7-, 2.2-, 1.8-, and 1.9-fold than in PBS, PBS + NIR, Free M + A, Free M + A + NIR, LDC@ZnP-M NPs + NIR, LDC@ZnP-A NPs treated groups, respectively (Fig. 7D and H).