ALK and colorectal carcinoma: For example, the interaction between USP5 and oxysterol-binding protein-related protein 8 (ORP8) facilitated the accumulation of ORP8 via USP5-mediated deubiquitination, leading to aggravation of ER (endoplasmic reticulum) stress in CRC cells treated with brigatinib, which was an anaplastic lymphoma kinase (ALK) inhibitor and originally approved for ALK-positive NSCLC, thus promoting apoptotic cell death of CRC cells [137].