TP53 and neoplasm: Another study constructed a prognostic model including SIRI, and through enrichment analysis, it was found that tumor neutrophil albumin related genes may be involved in the following pathways: cell cycle, homologous recombination, P53 signaling pathway, pyrimidine metabolism, etc. Therefore, Siri may affect the development of tumors by influencing the these signaling pathways through neutrophil related genes [45].