IL6 and neoplasm: Notably, by 7 months old, the livers of HDAC3LCKO&IL-6−/− female mice had a considerable number of tumour nodules (91%, 10/11), whereas the livers of HDAC3LCKO&IL-6−/− male mice had only smaller tumour nodules (36%, 4/11) (Fig. 4A and B).