To determine the impact of weight loss, gene and protein expression of DRD1 and DRD2 was also measured in SAT from subjects with obesity and T2D, before (baseline) and at several time points after the RYGB surgery (at 4, 24, and 104 weeks post-RYGB; cohort 1) (Fig. 3). The gene discussed is DRD2; the disease is obesity due to melanocortin 4 receptor deficiency.