The lasso model included multiple PGS for 18 different traits, including CHD, T2D, and cerebral grey matter volume as well as various PGS for traits and biomarkers that we had not included in the UK Biobank lasso model, such as cystatin C, lipoprotein (a), HbA1c, multiple sclerosis, and brain and eye measurements. Here, CST3 is linked to type 2 diabetes mellitus.