The association of the PDGFRA gene region with corneal astigmatism (≤ − 0.75 D) was replicated in a UK European ancestry cohort (n = 1968), and the minor allele T of another intronic SNP, rs6554163, showed the strongest association with an increased risk (OR = 1.24) of the disease10. This evidence concerns the gene PDGFRA and Astigmatism.