Furthermore, a large-scale GWAS for corneal astigmatism analyzed as a continuous trait with individuals of European ancestry from the UK Biobank (n = 86,335) reported a strong association between corneal astigmatism and PDGFRA and the minor allele C of a lead SNP, rs4864857, which contributed to an increased risk of the disease (effect size = 0.017)12. This evidence concerns the gene PDGFRA and Corneal astigmatism.