We recruited 1,535 cases with corneal astigmatism (mean corneal cylinder power across both eyes: ≤  − 0.75 diopters [D]) and 842 controls (> − 0.75 D) to genotype 13 single-nucleotide polymorphisms (SNPs) in the PDGFRA gene region. This evidence concerns the gene PDGFRA and Corneal astigmatism.