PDGFRA and Corneal astigmatism: For the cases with corneal astigmatism ≤  − 1.50 D, a significant association was observed for six SNPs which are located between 13 and 20 kb upstream of PDGFRA, including rs11133315 (Pc = 0.038, OR = 1.39) (Fig. 1b and Supplementary Table S2).