Since metformin and simvastatin regulate and inhibit YAP/TAZ transcriptional activity via different mechanisms18,19, we hypothesized that the combination of low doses of metformin and simvastatin attenuates pancreatic cancer development in the KC mouse model with diet-induced obesity, while the administration of each drug alone at low concentration has no effect. This evidence concerns the gene WWTR1 and keratoconus.