As alpha smooth muscle actin-positive pancreatic stellate cells express YAP and TAZ in human and murine PDAC27, an inhibitory action of metformin and statins on YAP/TAZ activity, as seen in our study, can plausibly disrupt the pro-fibroinflammatory role of pancreatic stellate cells and the pro-tumorigenic crosstalk between stellate and cancer cells37. This evidence concerns the gene WWTR1 and cancer.