MKI67 and keratoconus: While 7.6 ± 2.0% of PanIN cells in male KC mice fed the HFCD showed positive Ki67 staining, this percentage was reduced to 2.8 ± 1.5% in male KC mice fed the HFCD plus metformin and simvastatin (p = 0.04; Fig. 3F, G).