Two recent studies, one from our group (Munkley et al. [30]) and one by Shah et al. [32], identified a novel gene expression axis controlling epithelial splicing patterns in prostate cancer cells: androgen levels control expression of ESRP1 and ESRP2 proteins, which then control downstream epithelial splicing patterns [30, 32]. The gene discussed is ESRP2; the disease is prostate cancer.