To study the role of irf5, tgif1, irf8, cebpa, rorca and ikzf1 on thrombocyte production in zebrafish larvae, we injected the VMO/ASO hybrids for each of the above genes in 3 dpf larvae followed by the laser-induced arterial thrombosis assay in 5 dpf larvae and TTO was measured. The gene discussed is IRF8; the disease is deep vein thrombosis.