In comparison with the coculture systems with SCLC-A/N/P cells (SHP77, H446, and H526) and PBMCs, the coculture systems containing tumor cells with high YAP1 expression (DMS114 and H2286) had significantly lower proportions of CD45 + CD3 + CD4-CD8+Granzyme-B + T cells (16% vs. 22%, p = 0.028) and activated immune cells (CD45 + HLA-DR + ; 13.59% vs. 27.23%, p = 0.044; Fig. 6B). This evidence concerns the gene CD4 and small cell lung carcinoma.