Dan et al.75 demonstrated that 8-months after infection, B cell responses were relatively maintained in patient sera, while the CD4 and CD8 T cell responses decreased over time suggesting that if we extended our recovery period after SARS-CoV-2 exposure the humoral response may be sustained, while the decrease of CD4 cells over time may affect the germinal center response through a T follicular helper cell-dependent mechanism80–82. The gene discussed is CD4; the disease is infection.