Indeed, there is strong evidence for the ability of interstitial fluid flow to enhance the glioma cell invasion via the CXCR4/CXCL12 signaling axis.20 Interstitial fluid flow can also control breast cancer cell ameboid migration,21 and transcellular CCR7 ligand gradients can reportedly be shaped by this interstitial flow, thereby promoting the migratory activity of tumor cells and associated LNM.22 Interstitial flow can also promote macrophage M2 polarization and enable these cells to travel against this flow to access tumors, thus contributing to metastatic progression.23 The gene discussed is CCR7; the disease is neoplasm.