We ruled out that a chronic exposure to those exosomes switches the hepatocytes toward a NAFLD-like genotype and phenotype, by inducing ELOVL6 and SCD1 expression, which, in turn, activated TNF-α, RIP-1, and MLKL mediated necroptosis [52]. The gene discussed is ELOVL6; the disease is metabolic dysfunction-associated steatotic liver disease.