Moreover, PARP14 expression in short-term melanoma cell cultures derived from ICBT-progressing lesions was significantly negatively correlated with the infiltration of B cells and NK cells in the tumour microenvironment, suggesting that the higher PARP14 expression in tumour cells, the colder the tumour immune microenvironment (Supplementary Fig. 13D, E). This evidence concerns the gene PARP14 and neoplasm.