GZMB and neoplasm: Compared to control-treated tumours, the combination of α-PD-1 and PARP14i elicited an increased percentage of CD8+ T cells and a decreased percentage of Treg cells, leading to a significant increase in the ratio of CD8+ Granzyme B+ (GzmB+) cytotoxic lymphocytes (CTLs) to Treg cells (Fig. 6B–E and Supplementary Fig. 10 for gating strategy).