The T-cell subsets T-5 and T-20, two CD8+ naive subsets with bone marrow homing (CXCR4 + ) [36] and cytotoxic (NKG2D + , CD226 + , respectively) receptors were decreased in patients who later developed tMN as was the T-1 T cell subset described above. Here, CD226 is linked to therapy-related myeloid neoplasm.