On the other hand, when performing immunohistochemistry using Nestin as a marker to identify GBM cells [31, 32], tumor cells (Nestin + ) presented strong reactive gliosis given the co-distribution of Vimentin (green) and GFAP (white) in the control, IKE and IKE + DHAA+Lpx conditions in the tumor area (Fig. 5g,). Here, NES is linked to glioblastoma.