NES and neoplasm: Unexpectedly, treatment with IKE induced the migration of Nestin+ cells to various parenchymal areas and to the third ventricle (Fig. 5g, arrow), a finding that suggests that in response to IKE, GBM cells “escape” the tumor area by invading other regions, eventually increasing the aggressiveness of the GBM, similar to what occurs in patients treated with sulfasalazine [33].