Chemotherapy for HCC, especially in Asia, is still being studied, although HCC is recognized as one of the most drug-resistant tumors, and many chemotherapy drugs or regimens12 have been indicated to be ineffective for HCC or have intolerable toxicity, and some of these regimes include doxorubicin, cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF), and gemcitabine plus cisplatin/oxaliplatin. The gene discussed is IFNA2; the disease is hepatocellular carcinoma.