PDXK and ischemic stroke: Here, we find that natural product P57 induces hypothermia by targeting pyridoxal kinase (PDXK), a key metabolic enzyme of vitamin B6 catalyzing phosphorylation of pyridoxal (PL), resulting in the accumulation of PL in hypothalamus, and has a great neuroprotective effect in the ischemic stroke model, direct injection of the compound into the POA can lead to similar hypothermia effects.