We deduced that ZNF513 mutation led to the elevated expression of KIF3C and SOS1; meanwhile, KIF3C mutation led to the activation of PI3K and elevated KCNQ1 expression, which led to accelerated fibrosis of gingival fibroblasts and the enhanced proliferation and migration of fibroblasts, and finally led to the development of gingival fibromatosis (Fig. 8). This evidence concerns the gene PIK3CB and hereditary gingival fibromatosis.