In stable cell lines with lentivirus overexpressing ZNF513 and a ZNF513 knockout HGF cell line, we found that ZNF513 played an important positive role in regulating the expression of KIF3C and SOS1. Moreover, the ZNF513 c.C748T mutation enhanced the expression of KIF3C or SOS1, thus indirectly promoting the proliferation and migration of gingival fibroblasts and the development of gingival tumors. Here, SOS1 is linked to gingival neoplasm.