KIF3A and esophageal cancer: KIF3C is a molecular chaperone of KIF3A, and together they generate the heterodimer KIF3AC to participate in intracellular transport.30KIF3C is highly expressed in glioma, small cell lung cancer, esophageal cancer, and other cancers.31,32 It is even considered as a potential therapeutic target for solid tumors; for example, reducing the expression of KIF3C inhibits the proliferation and metastasis of breast cancer.31,33 The above studies suggest that high expression of KIF3C may cause a disruption of cell division leading to tumorigenesis.