Díez et al. observed that SARS-CoV-2 hyperimmune immunoglobulin from human convalescent plasma induced ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity) and ADCP (Antibody-dependent cellular phagocytosis) against SARSCoV-2 N and S [53], suggesting that role of antibodies against SARS-CoV-2 N protein in these mechanisms could be a determining factor in resolving SARS-CoV-2 infections through an S-protein independent mechanism involving host immune system cells [53]. Here, PROS1 is linked to COVID-19.