This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54). The gene discussed is APOE; the disease is Alzheimer disease.