Our group and others have found many immune system perturbations in HIV-1-infected individuals who made bnAbs compared to those that did not, which included HIV-1 infection-induced loss of CD4+ T regulatory cells [25], decreased NK suppression of CD4+ T follicular helper cells (TFH) [26], an expanded autoreactive B cell repertoire [27▪] and a higher circulating memory TFH frequency [25,28]. The gene discussed is CD4; the disease is HIV-1 infection.