SERPINE1 and irritable bowel syndrome: In accordance with the elevated gene expression, the number of PAI-1 positive cells was significantly higher in biopsy samples obtained from the inflamed part of the colon [IBD vs control: 18.52% vs 5.718%, p = 0.0014; IBD vs inactive IBD: 18.52% vs 6.651%, p = 0.0126], whereas the non-inflamed part showed no difference when compared with control samples [5.716% vs 6.641%, p >0.9999; Figure 3B].