SERPINE1 and irritable bowel syndrome: Several recent studies reported that the AUC of FC is between 0.8 and 0.9 in different patient populations,38–40 which increased above 0.9 when FC was combined with other markers, such as oncostatin M.40 In our experiments, faecal PAI-1 concentration was significantly higher in active IBD patients compared with the controls [AUC = 0.83] and in active versus inactive IBD and control samples [AUC = 0.82].