SERPINE1 and irritable bowel syndrome: Moreover, the PAI-1 concentration in the organoids [35.29 vs 0.00 ng/g, p = 0.0286; Figure 4C] and in the medium [31.28 vs 28.50 ng/g, p = 0.0423; Figure 4D] were significantly higher in the IBD organoids compared with the control.