Furthermore, ROC curves demonstrated that serum PAI-1 showed a moderate power to distinguish between active and inactive IBD patients (area under the curve [AUC] = 0.71; specificity: 48%; sensitivity: 87%; cut-off: 19.99 ng/mL; Figure 1F) and between controls and active IBD patients [AUC = 0.69; specificity: 48%; sensitivity: 87%; cut-off: 27.96 ng/mL; Figure 1G]. The gene discussed is SERPINE1; the disease is irritable bowel syndrome.