ROC curves demonstrated that mucosal PAI-1 showed a relatively high power to distinguish between active and inactive IBD patients [AUC = 0.81; specificity: 83%; sensitivity: 72%; cut-off: 18.16 pg/mg; Figure 3H] and between controls and active IBD patients [AUC = 0.88; specificity: 100%; sensitivity: 72%; cut-off: 15.49 pg/mg; Figure 3I]. Here, SERPINE1 is linked to inflammatory bowel disease.