Notably, a large number of studies have demonstrated relatively poor sensitivity and specificity of serum biomarkers in IBD diagnosis and patient monitoring.32,34,35 For example, studies showed that CRP is in the normal range in ~50% of UC patients.35,36 This was also confirmed in our cohort, as the patients with UC displayed significantly lower CRP levels than those with CD. This evidence concerns the gene CRP and inflammatory bowel disease.