Next, to evaluate the clinical relevance of these findings, we interrogated 2 independent CRPC patient transcriptome cohorts (Stand Up to Cancer/Prostate Cancer Foundation [SU2C/PCF], n = 159; ICR/Royal Marsden Hospital [ICR/RMH], n = 95) to determine whether DNA-PKcs (PRKDC) mRNA expression was associated with AR/AR-V7 mRNA and AR/AR-V7 activity scores (Supplemental Figure 20A) (20, 49, 50). This evidence concerns the gene PRKDC and prostate cancer.