We, therefore, reasoned that an unbiased interactome analysis of AR-V7 in CWR22Rv1-AR-EK cells, a CWR22Rv1 derivative expressing only AR-Vs (16), would validate AR-V7-DNA-PK interactions and support downstream analysis of DNA-PK–mediated regulation of AR-Vs in advanced PC. The gene discussed is AR; the disease is pachyonychia congenita.