On the other hand, in people with type 2 diabetes, exendin 9-39 increased fasting (12 ± 2 pmol/min versus 17 ± 2 pmol/min, P = 0.01) and nadir (6 ± 1 pmol/min versus 9 ± 2 pmol/min, P = 0.02) glucagon secretion. This evidence concerns the gene GCG and type 2 diabetes mellitus.