During the clamp, EGP suppression by hyperglycemia and endogenous insulin secretion was impaired so that at the end of the clamp EGP was higher in the presence of exendin 9-39 (2.9 ± 0.4 μmol/kg/min versus 5.7 ± 0.3 μmol/kg/min, P < 0.01 [Figure 5B]). The gene discussed is INS; the disease is Hyperglycemia.