INS and Hyperglycemia: In people without diabetes (Figure 3C), the incremental increase in integrated insulin concentrations during the first 30 minutes of hyperglycemia was decreased by exendin 9-39 infusion (3.0 ± 0.5 nmol/L versus 1.8 ± 0.3 nmol/L per 30 minutes, P < 0.01).