ACE and miotic rate: Univariate determinants of progression to moderate MR and above included: age, sex, CCI, presence of atrial fibrillation (AF), LVEF, LVEDD, LVESD, LA size, statin use, diuretics, and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEI and ARB; all P≤.03); the telehealth group was not associated with MR progression (hazard ratio [HR] 1.10, 95% CI 0.80-1.52; P=.52).